Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis.

نویسندگان

  • Min Xu
  • Marc Litaudon
  • Sabrina Krief
  • Marie-Thérèse Martin
  • John Kasenene
  • Bernard Kiremire
  • Vincent Dumontet
  • Françoise Guéritte
چکیده

One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11alpha-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9alpha-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD(2)Cl(2) at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.

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Antimicrobial Drimane Sesquiterpenes Contribute to Balanced Antagonism but Do Not Structure Bacterial and Fungal Endophytes in the African Pepper Bark Tree Warburgia ugandensis

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عنوان ژورنال:
  • Molecules

دوره 14 10  شماره 

صفحات  -

تاریخ انتشار 2009